Preheat your oven to 375°F (190°C) for a perfectly crispy exterior.
Carefully slice the jalapeño peppers in half lengthwise and remove the seeds. Wear gloves to avoid irritation.
In a mixing bowl, combine the cream cheese, cheddar cheese, garlic powder, onion powder, salt, and black pepper. Mix until creamy.
Using a spoon or piping bag, fill each jalapeño half with the cheese mixture, packing it well.
Place the filled jalapeños on a baking sheet lined with parchment paper, spaced evenly.
Bake the poppers for 20-25 minutes until the cheese is bubbly and jalapeños are tender. Broil for an additional 2-3 minutes if desired.
Let the poppers cool for a few minutes before serving warm.